Influence of parecoxib (cox-2 inhibitor) in experimental pleurodesis
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چکیده
منابع مشابه
Selective COX-2 inhibitor celecoxib prevents experimental autoimmune encephalomyelitis through COX-2-independent pathway.
Cyclooxygenase (COX) is a key enzyme of arachidonic acid metabolism and exists as two distinct isoforms. COX-1 is constitutively expressed in most tissues, whereas COX-2 is inducibly expressed at the site of inflammation. Selective inhibitors of COX-2 have been developed and have been used as anti-inflammatory agents. Here, we show that a new-generation COX-2 inhibitor, celecoxib, inhibited exp...
متن کاملCOX-2 inhibitor.
he developed severe psoriasis responsive only to repeated courses of the then newly available PUVA (psoralen plus UVA radiation) therapy. Between 1973 and 1993 he received PUVA once a week. During treatment no genital protection was used although he had never received UV therapy directly to the genital area. Two years after the onset of psoriasis he developed peripheral inflammatory arthritis. ...
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Cyclooxygenase (COX)-2 inhibitors are widely used for postoperative pain control in clinical practice. However, it is unknown whether spinal sensitization is involved in the analgesic effects of COX-2 inhibitors on surgical pain. Extracellular signal-regulated kinase (ERK) in the spinal cord is implicated in various types of pain, including surgical pain. The present study investigated the role...
متن کاملAntimicrobial Activity of Cox-2 Inhibitor
The present study was undertaken to evaluate the antimicrobial activity of Etoricoxib. At various concentrations, ranging from 20-100 μg/ml, Etoricoxib exhibits zone of inhibition of 6.5, 7, 8 and 13 respectively against p. aeruginosa while, it showed zone of inhibition of 10, 15, 18 against S. aureus and 8, 15 21 against E.coli at the concentration range of 25-100 μg/ml. It showed more activit...
متن کاملComplications of the COX-2 inhibitors parecoxib and valdecoxib after cardiac surgery.
BACKGROUND Valdecoxib and its intravenous prodrug parecoxib are used to treat postoperative pain but may involve risk after coronary-artery bypass grafting (CABG). We conducted a randomized trial to assess the safety of these drugs after CABG. METHODS In this randomized, double-blind study involving 10 days of treatment and 30 days of follow-up, 1671 patients were randomly assigned to receive...
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ژورنال
عنوان ژورنال: Respiratory Medicine
سال: 2009
ISSN: 0954-6111
DOI: 10.1016/j.rmed.2008.10.016